p27KIP1 and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice

p27KIP1 and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice

PTEN acts as a phosphatase for PIP3 and negatively regulates the PI3K/AKT pathway, and p27(KIP1) is a cyclin-dependent kinase inhibitor that regulates the G1 to S-phase transition by binding to and regulating the activity of cyclin-dependent kinases. Genetic alterations of PTEN or CDKN1B (p27(KIP1)) are common in hematological malignancies. To better understand how mutations in these two genes ...

Tenets of PTEN Tumor Suppression

Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor types. A decade of work has established that PTEN is a nonredundant phosphatase that is essential for regulating the highly oncogenic prosurvival PI3K/AKT signaling pathway. This review discusses emerging modes of PTE...

Low-dose methotrexate in myeloproliferative neoplasm models.

PTEN level in tumor suppression: how much is too little?

The importance of PTEN (phosphatase and tensin homolog located on chromosome 10) in cancer has surpassed all predictions and expectations from the time it was discovered and has qualified this gene as one of the most commonly mutated and deleted tumor suppressors in human cancer. PTEN levels are frequently found downregulated in cancer, even in the absence of genetic loss or mutation. PTEN is h...

The Multiple Roles of PTEN in Tumor Suppression

missense mutations in PTEN detected in primary tumors and in cell lines are confined to exon 5, which encodes this domain. Despite its homology with dual-specificity phosphatases, PTEN is an inefficient protein phospha-tase in vitro; however, it is very active on highly acidic Sloan-Kettering Institute New York, New York 10021 substrates. This finding suggested that the substrates of PTEN might...